Cutaneous squamous cell carcinoma (cSCC) is an increasing public health problem. It is a primary malignant skin tumor with\nMalpighian differentiation and together with basal cell carcinoma is classified among nonmelanoma skin cancers (NMSCs). cSCC\nusually occurs on photoexposed areas, such as the head, the neck, and the extremities, and its incidence increases with age. Invasive\nforms of this skin tumor tend to be more aggressive showing a higher metastatic potential, usually regarding regional lymph nodes.\nTreatment options for invasive cSCCs include both surgical and nonsurgical options. The therapeutic choice depends on several\nfactors, such as anatomic location, risk factors for tumor recurrence, age, and health status of the patient. This reviewaims toprovide\nan overview of the current evidence on therapeutic surgical and nonsurgical management of invasive cSCC.
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